Endostatin appeared on the front page of the New York Times in 1998 in an article that drew a deluge of publicity to Folkman's research.
Folkman said that he is much more cautious now when he talks to the press, rejecting thousands of requests for interviews a year.
"As a physician, you have to be really careful if you over-raise expectations," Folkman said.
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Folkman's laboratory at Children's Hospital has also developed Angiostatin and thalidomide--two drugs other than 2ME2 and Endostatin that also disrupt blood flow to tumor cells.
The Medical School's Associate Professor of Ophthalmology Robert J. D'Amato first discovered the 2ME2 molecule in urine, a result published about three to four years ago, according to Folkman.