He gave as an example the task of designing the Museum of Modern Art in Frankfurt. The Museum was planned for a tight triangular space close to a cathedral. Hollein envisioned the cathedral as a "ship," and created an edifice resembling a "ship" traveling in the opposite direction.
His other creations include the Bilbao Guggenheim Museum and the Feigen Gallery in New York.
In 1985, Hollein received the Pritzker Prize, the highest honor attainable in the field of architecture.