Brad Miller had a career-high 31 points and eight rebounds and Purdue scored the first six points in overtime.

Freshman Brian Cardinal, whose 3-pointer with 16 seconds left in regulation forced OT, hit the first basket in the extra period, and Purdue (18-11) never trailed again.

The Rams (20-9) had their chances to win in regulation. But Tyson Wheeler's leaner bounced off, and Michael Andersen missed the follow before the buzzer.

Colorado 80, Indiana 62

Chauncey Billups scored 24 points as Colorado handed Indiana an opening-round defeat for the third straight year.

Billups, a second-team All-American, scored 20 points in the first half as Colorado built a 46-31 lead. The Buffaloes (22-9), making their first NCAA appearance in 28 years, went on to beat Indiana (22-11) by 18 points, matching the Hoosier's worst NCAA tournament defeat in 71 games.

Villanova 101, LIU 91

LIU, the nation's highest scoring team, got a lesson in fast-paced basketball. The fourth-seeded Wildcats (24-9) used an 8-0 run to end the first half and a 19-1 barrage in the opening three and a half minutes of the second half to blitz the Blackbirds.

Freshman Tim Thomas had 28 points and 15 rebounds, while Jason Lawson added 21 points, 12 rebounds and seven blocks. Charles Jones, the nation's leading scorer, had 37 to lead No. 13 seed LIU.

Kansas 78, Jackson St. 64

Scot Pollard, coming back from a broken foot, grabbed a career-high 19 rebounds to go with six blocks and 12 points in top-ranked Kansas' victory.

Pollard, All-American Raef LaFrentz and Paul Pierce overwhelmed 16th-seeded Jackson State. LaFrentz had 18 points, 14 rebounds and three blocks, and Pierce had 19 points, 13 rebounds and four blocks as Kansas (33-1) had a 61-27 rebounding advantage.

Arizona 65, S. Alabama 57

Arizona outscored South Alabama 22-4 in the final seven and a half minutes to overcome a 10-point deficit.

Miles Simon scored nine of his 11 points during that late stretch. The rally allowed Arizona (20-9) to avoid losing in the first round for the fourth time in six years.