After asking a man in the audience, "Do you know anything about women?" Poundstone pointed to the undergraduate Women's Studies concentrator.
"Would you mind telling her?" she asked, adding, "I'm going to whip you through this women's studies stuff."
Poundstone ridiculed the idea of 1993 as the "Year of the Woman," asking, "What fat white guy came up with that phrase?"
Poundstone said the fact that six women were elected to the Senate that year was not a feat to celebrate, because women comprise 52 percent of the population of the United States. "Apparently women do suck at math," Poundstone added.
Poundstone did not stop at women's issues.
Of Will Perkins, the leader of Colorado Family Values, a group instrumental in passing the famous "antigay" amendment she said, "He can relate to homosexuals, he says, because he's a car salesman. 'People make fun of our pants and our white shoes.' Yes, that is so similar. That must be hell for you."
After poking fun at women's issues and politics, Poundstone returned to her tour of Ivy League humor, noting researchers at Stanford University have discovered why people were often tired on Monday.
"Because oftentimes, they stay up late Friday and Saturday. How could that be? Dammit, it's not possible," she joked.
Poundstone also commented on MIT's motto, "Minds and Hands."
"You know what you might be confusing that with?" she asked a former MIT student in the audience. "Head & Shoulders, knees and toes."
Poundstone concluded her show with a commentary on her tendency to talk, just before the Harvard Band stomped in with its rendition of "Ten Thousand Men of Harvard":
"If you weren't even here, I'd still be doing this. I just can't shut up...Martin Luther King could come to my hotel room tonight and say 'I had a dream,' and I'd go, 'Oh yeah, I had a dream too...'