LOWELL, Mass.—Flushing out campaign trail accusations and platform promises, U.S. Senator Scott Brown and Democratic challenger Elizabeth Warren disagreed on job creation, tax policy, and immigration reform Monday during the second debate for the Massachusetts U.S. Senate race.

Guided by moderator David Gregory, host of NBC’s “Meet the Press,” the candidates weighed in on everything from tax policy to the withdrawal from Afghanistan, helping to advance dueling campaign narratives and political visions in the hour long, prime time debate.

Warren, a Harvard Law School professor and political newcomer, said her priority as a senator would be fixing a broken system for the working families of Massachusetts. Citing jobs bills, research grants, and infrastructure, Warren laid out a populist message that has become familiar in recent weeks.

“I will work with anyone—Republican, Democrat, Libertarian, vegetarian—if they will work for America’s families,” Warren said.

But when asked to name a Republican member in Congress she would be willing to work with, Warren came up blank. Brown seized the opportunity highlight his own bipartisan record in the Senate.

“I don’t work for anybody,” Brown said. “A good idea is a good idea no matter where it comes from.”

The exchange was repeated in various forms throughout the night as Brown pushed his bipartisanship and Warren’s strong ideological stances. He said he was willing to back legislation that would benefit Massachusetts and the country, and not necessarily that which the Republican party supports. Brown went as far as to praise the president’s handling of Afghanistan and his work on the bi-partisan STOCK Act—a measure Brown co-sponsored. The Senator dodged questions about the distance he has created for himself from former Mass. Gov. Mitt Romney.

As in the first debate, much of the first 30 minutes Monday were dedicated to character attacks that have predominated the race in recent weeks. Gregory pressed Brown to clarify charges he has made that Warren gained an unfair advantage while at Harvard by identifying as Native American. He also pushed the senator to better-define his claims that Warren advocated against the working voters as a corporate counsel for Travelers Insurance and LTV Steel.

“I think character is how you live your life,” Warren said, later adding, “I have worked hard for 30 years to make the legal system just a little bit fairer for people. I think that is a good test of character.”

Though they agreed to withdraw troops from Afghanistan and not to raise taxes on working class families, Brown and Warren disagreed on how to fix the economy and reform the country’s immigration system. At times, the debate became heated as both candidates fought to address charges leveled against them. “Excuse me, I'm not a student in your classroom, please let me respond,” Brown said during a back and forth about three jobs bills he voted against last fall.

Warren accused Brown of missing out on too many chances to help Massachusetts unemployed by generating jobs and cutting oil subsidies. Warren expressed her own support for the bipartisan Simpson-Bowles Plan, which would fill the budget deficit with combined spending cuts and revenue increases. She also said she would support the President’s jobs bill.

Brown countered Warren’s claims, saying the problem’s weighing on the economy had more to do with regulations and taxes than a lack of government spending.

“People are concerned,” Brown said. “They don’t know what’s next...and as a result there are less people hiring.”

The candidates diverged again when discussing the Dream Act, which would grant amnesty to certain illegal immigrants brought into the country as children. Though both agreed there was need for broad immigration policy reform, Brown said he could not support the act.

“I am in favor of full legal immigration,” Brown said. “In terms of the Dream Act, no I don’t support it. It's a form of backdoor amnesty.”

The candidates will meet in central Massachusetts for an Oct. 10 debate in Springfield before finishing their debate schedule in Boston on Oct. 30, just a week ahead of election day.

—Staff writer Nicholas P. Fandos can be reached at nicholasfandos@college.harvard.edu.